There are an abundance of tools at FantasyLabs to use for your NFL DFS lineups each week. Our most popular tools are our NFL Player Models, which house our NFL DFS projections from Sean Koerner.
You can use these projections in our models with our Lineup Builder to hand-build your lineups or use our Lineup Optimizer to effortlessly create up to 300 lineups for your NFL DFS tournaments.
In this article, we will go position by position, highlighting my favorite plays for both cash games and single-entry/three-max GPP contests. These plays are also viable in large field tournaments but do not focus on ownership percentages.
NFL DFS Cash Game + Single-Entry GPP Locks
NFL DFS Quarterback Picks
Patrick Mahomes ($8,000 DraftKings, $9,200 FanDuel) Kansas City Chiefs vs. Jacksonville Jaguars
For some strange reason it feels like Mahomes is going overlooked this week with most seemingly gravitating to Josh Allen and Jalen Hurts. Granted, those two are great plays, but Mahomes is in arguably the best spot of any QB playing on Divisional Weekend. The Chiefs have the highest implied team total on the slate at 30.75, which is three points clear of the Eagles, who hold the second highest.
Mahomes is also a completely different animal in the postseason. Last year he threw for 405 yards and five touchdowns against the Steelers, 378 yards and three touchdowns against the Bills, and then a lackluster 275/3 performance against the Bengals. He also rushed for a combined 117 yards and a touchdown in last year’s three playoff games, which only further illustrates his ceiling.
The Chiefs will likely lean more pass-heavy now that the real season is beginning and the odds of Mahomes not throwing for 300 and three in this spot seems incredibly slim to me.
Mahomes is a negligible $200 more than Allen and $400 more than Hurts, but everyone seems hell-bent on taking the discount, as he projects third among the trio in ownership.
NFL DFS Running Back Picks
Miles Sanders ($5,700 DraftKings, $7,200 FanDuel) Philadelphia Eagles vs. New York Giants
The Giants took out one of the most fraudulent teams in the NFL last week in the Vikings, but it feels like many are ready to crown them. I believe they will be in for a rude awakening this week against a far superior Eagles team. Jalen Hurts is off the injury report for the first time since he got hurt, and Philly is well-rested. I mention all this because Miles Sanders has not had a good game in six weeks, which was ironically the week before Hurts injured his shoulder.
In that game, which was against the Giants, by the way, Sanders ran for 144 yards and two touchdowns. The Eagles are a dynamic rushing team when Hurts is healthy, and with him off the injury report, I am expecting a big performance from Sanders Saturday night. Sanders went over 30 DK points three different times this season, which is as many as Saquon Barkley, Joe Mixon, Tony Pollard, and Travis Etienne Jr. hit combined.
Sanders’ $5,700 price tag is also quite appealing, especially when you consider he boasts the fifth shortest odds on the slate to score a touchdown (-115) on DraftKings Sportsbook. If the Eagles hit their team total (27.75), Sanders can easily hit the 100-yard bonus and find paydirt.
NFL DFS Wide Receiver Picks
Zay Jones ($4,700 DraftKings, $6,500 FanDuel) Jacksonville Jaguars @ Kansas City Chiefs
Christian Kirk also works in this spot, but this is the position where most of the value lives, especially if you want to spend up for CMC, which is recommended. After a couple of bad games in a row, Jones looked great against the Chargers last week, catching eight of his 13 targets for 74 yards, good for 21.4 DK points. The last time the Chiefs played Jacksonville was Week 10, where Jones caught eight passes for 68 yards.
Things could get ugly quickly for the Jaguars this week, and I would expect Kansas City to allow a ton of underneath production if they build a big lead. Jones is in a great spot as the Chiefs rank 26th in DK points allowed to opposing wideouts.
At his price, all we’re looking for is 15 or so points, which he’s exceeded on multiple occasions this season. He also correlates quite well with Mahomes.
NFL DFS Tight End Picks
Travis Kelce ($7,700 DraftKings, $8,000 FanDuel) Kansas City Chiefs vs. Jacksonville Jaguars
Naturally, with Mahomes being my QB of choice this week, we have to stack him with his BFF, Kelce. I mentioned how Mahomes turns it on once the calendar flips to January, but Kelce REALLY turns it on. Here are the stat lines for his last six postseason games: 10/95/1, 8/96/1, 5/108/1, 10/133/0, 13/108/2, and 8/109/1.
This is not surprising, of course, because as Mahomes goes, Kelce goes, or maybe vice versa. Either way, Jacksonville has allowed the sixth most DK points to opposing tight ends this season and allowed a 6/81/1 line to Kelce earlier this year. If you couldn’t tell,
I am all in on the Chiefs in this spot and expect them to go for 35+ points, which would mean “having to have it” games from both Kelce and his QB.