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Daily Fantasy Football Week 10 NFL DFS Stacks and Picks on DraftKings and FanDuel

jaguars qb trevor lawrence

This piece will identify some of my favorite NFL DFS stacks of the weekend. Be sure to use our Stacking tool within our Player Models to find the highest projected stacks, the stacks that figure to be chalky, and more. Our Correlation Dashboard is also an excellent resource for finding hidden edges in stacking positions and games.

You can also plug these stacks into our Lineup Builder to hand-build the rest of it, or you can optimize it with our projections. And if you like to create multiple lineups, our Lineup Optimizer allows you to effortlessly create up to 300 lineups.

The Lineup Optimizer has endless customization opportunities.

Try Our New SimLabs Tool!

We’re excited to announce the launch of our new NFL DFS simulations tool! Try SimLabs for FREE while it’s still in beta.

Become an All-Access Member Today

Lineup builder and optimizer

Real-time DFS models & projections

Data-driven analysis & tutorials

Week 10 NFL DFS Stacks and Picks

Trevor Lawrence + Calvin Ridley + Evan Engram + Christian McCaffrey

  • Trevor Lawrence ($6,000 DraftKings, $7,100 FanDuel)
  • Calvin Ridley ($5,600 DraftKings, $6,700 FanDuel)
  • Evan Engram ($4,500 DraftKings, $5,600 FanDuel)
  • Christian McCaffrey ($9,200 DraftKings, $10,500 FanDuel)

There hasn’t really been a single back-and-forth game for Jacksonville, as they’ve pretty much cruised to victories as of late. I’m expecting both offenses to have a lot of success, and Trevor Lawrence is due to light up the stat sheet. He’s thrown multiple touchdowns in just two games, and Travis Etienne Jr. found paydirt on the ground six times in the past four weeks.

San Francisco is fresh off a bye and should be able to move the ball against this Jacksonville defense. The Jaguars are also coming off of a bye and have had more than enough time to scout this San Francisco unit. I’m expecting a lot of points here, and I think Lawrence has a 30+ point ceiling in a back-and-forth affair.

Calvin Ridley and Evan Engram are my two favorite stacking options, with Christian Kirk viable as well.

This matchup sets up very well for Ridley. Over half of his targets have been downfield, and he’s utilized consistently outside the numbers. San Francisco is allowing the most receptions per game and the third-most receiving yards per game to boundary receivers. To add a cherry on top, they’ve allowed the fourth-most DraftKings points to opposing receivers on the season.

Ridley is coming off of a 10-target performance before the bye. Ridley is super talented, and it wasn’t that long ago when people were chomping at the bit to play him at $7,200 early in the year.

Evan Engram has posted solid performances despite not finding the end zone. He’s averaging 11.7 DraftKings points per game with zero touchdowns.

He’s coming off some heavy usage before the bye, where he caught 10 of 10 targets for 88 yards. He’s seen at least seven targets in every game besides Week 1, as he’s consistently relied on in the offense.

He’ll need to make the most of his volume this week, with San Francisco allowing the fewest yards per target to opposing tight ends.

On the San Francisco side, Christian McCaffrey has found the end zone in every game this season, and now the 49ers welcome Trent Williams back into the lineup. McCaffrey has averaged 3.6 yards per carry with Williams off the field compared to 5.0 yards per carry with him on.

Jacksonville has been stout against opposing running backs on the ground but has allowed the most receptions to opposing backs on the year. McCaffrey is always capable of breaking a big run on the ground and could be poised to rack up the receptions in this spot.

With me hopping aboard the McCaffrey train, this is probably where the touchdown luck stops. So be aware.

Joe Burrow + Ja’Marr Chase + Trent Irwin + Tyler Boyd + Noah Brown and/or Tank Dell

  • Joe Burrow ($6,800 DraftKings, $8,200 FanDuel)
  • Ja’Marr Chase ($8,600 DraftKings, $9,300 FanDuel)
  • Tyler Boyd ($4,600 DraftKings, $6,200 FanDuel)
  • Trent Irwin ($3,000 DraftKings, $4,800 FanDuel)
  • Noah Brown ($3,700 DraftKings, $5,40 FanDuel)
  • Tank Dell ($5,500 DraftKings, $6,400 FanDuel)

Joe Burrow has topped 25 DraftKings points in three of his last four games. The most impressive of which came against San Francisco, where he threw three touchdowns against one of the top defenses in the league on the road.

This Texans defense has given up a lot of yards to opposing quarterbacks, but they’ve kept them out of the end zone. They’re likely due for negative regression in the touchdown department, and Burrow is ripe to take advantage of it.

With Tee Higgins out, Ja’Marr Chase and Tyler Boyd are likely to see all of the volume that they can handle. Trent Irwin is the minimum price on DraftKings and is running a full set of routes. He’s a very strong play.

The matchup appears difficult, with Houston surrendering the fourth-fewest DraftKings points per game to opposing receivers. However, they’ve allowed a bottom-ten catch rate and a healthy 8.0 yards per target, so they’re due to give up some solid scores.

On the Houston side, Nico Collins is out and Robert Woods is questionable. Tank Dell has been tearing it up, coming off 114 yards and two touchdowns. Noah Brown remains cheap while running a dropback on practically every route, and just put up 30.3 DraftKings points.

Be sure to check out all the pick’ems Sleeper has to offer with Sleeper Fantasy promo code LABS1 for a $100 deposit match.

This piece will identify some of my favorite NFL DFS stacks of the weekend. Be sure to use our Stacking tool within our Player Models to find the highest projected stacks, the stacks that figure to be chalky, and more. Our Correlation Dashboard is also an excellent resource for finding hidden edges in stacking positions and games.

You can also plug these stacks into our Lineup Builder to hand-build the rest of it, or you can optimize it with our projections. And if you like to create multiple lineups, our Lineup Optimizer allows you to effortlessly create up to 300 lineups.

The Lineup Optimizer has endless customization opportunities.

Try Our New SimLabs Tool!

We’re excited to announce the launch of our new NFL DFS simulations tool! Try SimLabs for FREE while it’s still in beta.

Become an All-Access Member Today

Lineup builder and optimizer

Real-time DFS models & projections

Data-driven analysis & tutorials

Week 10 NFL DFS Stacks and Picks

Trevor Lawrence + Calvin Ridley + Evan Engram + Christian McCaffrey

  • Trevor Lawrence ($6,000 DraftKings, $7,100 FanDuel)
  • Calvin Ridley ($5,600 DraftKings, $6,700 FanDuel)
  • Evan Engram ($4,500 DraftKings, $5,600 FanDuel)
  • Christian McCaffrey ($9,200 DraftKings, $10,500 FanDuel)

There hasn’t really been a single back-and-forth game for Jacksonville, as they’ve pretty much cruised to victories as of late. I’m expecting both offenses to have a lot of success, and Trevor Lawrence is due to light up the stat sheet. He’s thrown multiple touchdowns in just two games, and Travis Etienne Jr. found paydirt on the ground six times in the past four weeks.

San Francisco is fresh off a bye and should be able to move the ball against this Jacksonville defense. The Jaguars are also coming off of a bye and have had more than enough time to scout this San Francisco unit. I’m expecting a lot of points here, and I think Lawrence has a 30+ point ceiling in a back-and-forth affair.

Calvin Ridley and Evan Engram are my two favorite stacking options, with Christian Kirk viable as well.

This matchup sets up very well for Ridley. Over half of his targets have been downfield, and he’s utilized consistently outside the numbers. San Francisco is allowing the most receptions per game and the third-most receiving yards per game to boundary receivers. To add a cherry on top, they’ve allowed the fourth-most DraftKings points to opposing receivers on the season.

Ridley is coming off of a 10-target performance before the bye. Ridley is super talented, and it wasn’t that long ago when people were chomping at the bit to play him at $7,200 early in the year.

Evan Engram has posted solid performances despite not finding the end zone. He’s averaging 11.7 DraftKings points per game with zero touchdowns.

He’s coming off some heavy usage before the bye, where he caught 10 of 10 targets for 88 yards. He’s seen at least seven targets in every game besides Week 1, as he’s consistently relied on in the offense.

He’ll need to make the most of his volume this week, with San Francisco allowing the fewest yards per target to opposing tight ends.

On the San Francisco side, Christian McCaffrey has found the end zone in every game this season, and now the 49ers welcome Trent Williams back into the lineup. McCaffrey has averaged 3.6 yards per carry with Williams off the field compared to 5.0 yards per carry with him on.

Jacksonville has been stout against opposing running backs on the ground but has allowed the most receptions to opposing backs on the year. McCaffrey is always capable of breaking a big run on the ground and could be poised to rack up the receptions in this spot.

With me hopping aboard the McCaffrey train, this is probably where the touchdown luck stops. So be aware.

Joe Burrow + Ja’Marr Chase + Trent Irwin + Tyler Boyd + Noah Brown and/or Tank Dell

  • Joe Burrow ($6,800 DraftKings, $8,200 FanDuel)
  • Ja’Marr Chase ($8,600 DraftKings, $9,300 FanDuel)
  • Tyler Boyd ($4,600 DraftKings, $6,200 FanDuel)
  • Trent Irwin ($3,000 DraftKings, $4,800 FanDuel)
  • Noah Brown ($3,700 DraftKings, $5,40 FanDuel)
  • Tank Dell ($5,500 DraftKings, $6,400 FanDuel)

Joe Burrow has topped 25 DraftKings points in three of his last four games. The most impressive of which came against San Francisco, where he threw three touchdowns against one of the top defenses in the league on the road.

This Texans defense has given up a lot of yards to opposing quarterbacks, but they’ve kept them out of the end zone. They’re likely due for negative regression in the touchdown department, and Burrow is ripe to take advantage of it.

With Tee Higgins out, Ja’Marr Chase and Tyler Boyd are likely to see all of the volume that they can handle. Trent Irwin is the minimum price on DraftKings and is running a full set of routes. He’s a very strong play.

The matchup appears difficult, with Houston surrendering the fourth-fewest DraftKings points per game to opposing receivers. However, they’ve allowed a bottom-ten catch rate and a healthy 8.0 yards per target, so they’re due to give up some solid scores.

On the Houston side, Nico Collins is out and Robert Woods is questionable. Tank Dell has been tearing it up, coming off 114 yards and two touchdowns. Noah Brown remains cheap while running a dropback on practically every route, and just put up 30.3 DraftKings points.

Be sure to check out all the pick’ems Sleeper has to offer with Sleeper Fantasy promo code LABS1 for a $100 deposit match.

About the Author

Matt Martin writes NFL and XFL/USFL content for FantasyLabs. He just finished his undergrad in Finance and Sports Management. He is currently pursuing his Masters in Data Analytics. Prior to joining FantasyLabs in 2022, Martin started covering DFS in 2019 with Daily Fantasy Insider, and has spent time with the 33rd Team and reallygoodpicks.com.