Daily Fantasy Football Week 10 NFL DFS Stacks and Picks on DraftKings and FanDuel

This piece will identify some of my favorite NFL DFS stacks of the weekend. Be sure to use our Stacking Tool within our Player Models to find the highest projected stacks, the stacks that figure to be chalky, and more. Our Correlation Dashboard is also an excellent resource for finding hidden edges in stacking positions and games.

You can also plug these stacks into our Lineup Builder to hand-build the rest of it, or you can optimize it with our projections. And if you like to create multiple lineups, our Lineup Optimizer allows you to effortlessly create up to 300 lineups.

The Lineup Optimizer has endless customization opportunities.

Or you can just use our NFL DFS sims to effortlessly create advanced lineups.

Finally, make sure to check out all the projections available for purchase within the FantasyLabs Models. Subscribers now have the option to purchase Derek Carty’s THE BLITZ from our Marketplace.

You can also combine them to create your own aggregate projection:

Week 10 NFL DFS Stacks and Picks

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Brock Purdy + Christian McCaffrey + Keenan Allen + CeeDee Lamb

• Brock Purdy ($7,000 DraftKings, $8,700 FanDuel)
• Christian McCaffrey ($8,500 DraftKings, $9,000 FanDuel)
• Keenan Allen ($5,100 DraftKings, $6,000 FanDuel)
• CeeDee Lamb ($8,800 DraftKings, $9,000 FanDuel)

After a fairly successful stack last week, we’re running it right back with the San Francisco 49ers this week. They are yet again implied for the highest total on the slate at 29.75 points while being 4.5-point road favorites against the Dallas Cowboys. This game has by far the highest game total at 56 points. There is only one other game with a total that reaches 50 points. Prioritize this NFC showdown in Week 10.

49ers quarterback Brock Purdy continues to put up big numbers. The 49ers put up 38 points last week, and Purdy threw for 232 yards with two passing touchdowns. He added seven rushing attempts for 40 yards with a rushing touchdown. Purdy is an elite dual-threat quarterback and is popping in our NFL Models this week. The Cowboys defense has been a favorable matchup for opposing quarterbacks.

The Cowboys continue to rank 31st in defensive EPA per play while allowing a ridiculous 372.7 yards per game. They are allowing the sixth-most fantasy points to quarterbacks, making this a great week to roster Purdy and his offensive weapons. It is only a matter of time until Purdy gets his full arsenal back in action. However, there are still plenty of options to help him this week against a pitiful Cowboys passing defense.

Not only have the Cowboys been poor against the pass, but they have been even worse against the run. They are allowing 147.4 rushing yards per game, the second-highest mark in the league, and the most fantasy points to opposing running backs. That puts Christian McCaffrey in another incredible spot. He was in a great spot last week and posted one rushing and one receiving touchdown.

McCaffrey has the second-highest projected ceiling at the running back position and is drawing around 20% projected ownership. He has been the model of consistency, which is why he is such a popular play. McCaffrey has scored the fourth-most fantasy points per game among running backs, and after a slow week one, he is averaging 22 DraftKings points per game in his last seven contests with 10 touchdowns.

The 49ers’ wide receiving cast added help this week after trading for veteran Keenan Allen. That is who we are adding in this 49ers game stack due to his cheap mid-range price tag. Allen led the Colts in target share and receptions this season and adds a consistent option for Purdy. Mike Evans is leaning towards missing another week, and Deebo Samuel is in danger of missing his fourth consecutive game.

Keep an eye on the status of Evans and Samuel the closer we get to lock. If they remain out, as they are trending to do, then Allen is a fantastic option. Unlike other options on the 49ers, Allen is projected for less than 5% ownership, which makes this stack even more intriguing. It would not be surprising if Allen was inserted immediately into this offense and had double-digit targets if the injury news breaks his way.

The obvious bring-back for this 49ers stack is Cowboys wide receiver CeeDee Lamb. He is currently second in the league among wide receivers in receiving yards with 904 and has seven touchdowns. Lamb is coming off an explosive game against the Colts last week, hauling in 10 of his 16 targets for a season-high 195 yards and a touchdown. He nearly had a second touchdown but was unable to keep his feet in.

Fellow Cowboys receiver George Pickens was out last week, but he has been practicing in a limited fashion this week, so he is trending towards being back. Pickens is worth a look at his $6,300 salary, but Lamb is the preferred option if salary isn’t a problem. Lamb has separated himself as the top option. He has a 33% target share this season and has scored the second-most fantasy points per game for wide receivers.

With a total this high, there are many stacking avenues to take to get different. Adding Keenan Allen is a strong way to do that given his projected ownership, but mix and match this game when building several lineups. With a 56-point total, this is the premier game environment to target on this 10-game slate.

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Tyler Shough + Chris Olave + Chuba Hubbard

• Tyler Shough ($5,600 DraftKings, $7,300 FanDuel)
• Chris Olave ($7,000 DraftKings, $7,900 FanDuel)
• Chuba Hubbard ($7,200 DraftKings, $7,200 FanDuel)

For the first time in NFL history, a division has all four teams two games under .500 through Week 9. The NFC South is an absolute joke, but it is fully up for grabs. The New Orleans Saints are hosting the Carolina Panthers this week in a game that has a respectable 48.5-point total, which is the third-highest on the slate. The Saints are 2.5-point favorites, implied for 25.5 points. This is a matchup that is worth targeting.

Looking at our NFL Sims, Saints quarterback Tyler Shough is popping off the charts. He has a 24.3% optimal lineup rate, which is the highest among any quarterback by 14%. It is no secret, but Shough also has the highest projected Plus/Minus at the quarterback position at his favorable $5,600 salary. Outside of his awful game against the Vikings’ elite defense, Shough is averaging 22.3 DraftKings points per game.

After a hot start, the Panthers have lost three straight games, allowing an average of 32 points per game during that time. In Week 1, their defense allowed 59 points to the Chicago Bears. This is a matchup that Shough and company can attack. The Panthers rank first, and the Saints are second in the league in seconds per play, so expect a fast-paced game environment with plenty of options for fantasy production.

Shough leads the league with 43 dropbacks per game. The Saints run game has lost Travis Etienne Jr. to injured reserve, and the combination of Alvin Kamara and Audric Estime has been below average. The passing offense just added rookie wide receiver Jordyn Tyson last week, and he is reasonably priced at $5,000 this week. The Panthers are allowing the seventh-most fantasy points to opposing quarterbacks.

Even with Tyson back, the obvious stacking partner with Shough is Saints’ stud top receiver Chris Olave. He leads the team with a 29% target share and is averaging 91.8 receiving yards per game. Despite only producing two touchdowns this season, Olave is still averaging 18.8 DraftKings points per game, which is the ninth-most among wide receivers. He gets most of his production from receptions and receiving yards.

Pairing Olave with Shough will be popular but should be even more popular based on our NFL Sims. Olave has a 30.1% optimal lineup rate, which leads all wide receivers and is 10% more than the next closest. Among the top wide receivers in the league, Olave has the highest aDOT at 13.0 with a 46% air-yards share. He has received double-digit targets in six of his eight games this season. Olave is a fantastic option at $7,000.

The best way to attack the Saints defensively is on the ground. They are allowing 133.9 rushing yards per game, which is the fourth-most in the league. Running backs are also recording the second-most fantasy points against the Saints’ run defense. That is why Chuba Hubbard is going to be the ideal bring-back for this Saints stack. With Jonathan Brooks on injured reserve, Hubbard has been the lead back.

Hubbard has the second-highest projected Plus/Minus and the second-highest optimal lineup rate at the running back position. Since Week 3, when Brooks was out, Hubbard has handled 82% of the Panthers’ rushing attempts. He is averaging 19.1 DraftKings points per game this season and is one of the few three-down running backs in the league. Hubbard also has at least five targets in each of his last three contests.

The Shough + Olave + Hubbard game stack provides a ton of value with plenty of upside. In a game that is projected to be fast-paced, these three should have so much opportunity to accumulate fantasy points.

Pictured: Chris Olave
Photo Credit: Imagn