College Football DFS Picks: Week 6 CFB DraftKings Main Slate Breakdown (Saturday, October 10th)

It’s hard to believe that we’re already at the part of the season where Group of 6 action starts taking over at the start of the week. We’re here to soak up all of the college football action, including Tuesday night Sun Belt Conference beatings, but it’s a reminder of how quickly the college football season moves. We’re slowing things down in Week 6, taking our time to evaluate the main slate and ensure we’ve got the right pieces locked and loaded into our rosters. With several crucial conference matchups tied to the main slate, we’re being thoughtful about which players are set up for success on Saturday afternoon.

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We’ve got you covered for DFS purposes, highlighting our preferred players from Saturday’s main slate.

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Let’s dive into this week’s slate!

CFB DFS Quarterback Picks

Michael Hawkins (West Virginia Mountaineers): $9,000 DraftKings

The West Virginia Mountaineers defense has left the chat. WVU has given up 86 points in two straight losses, forcing its offense to do whatever is necessary to keep pace. The Mountaineers will have their work cut out for them against the Arizona Wildcats in Week 6. That certainly means big things from Michael Hawkins on the main slate.

As his slate-leading salary suggests, Hawkins has been one of the most reliable fantasy producers this season. The third-year sophomore has already thrown for 836 yards while breaking off 574 yards on the ground. His fantasy ceiling is further elevated by his unmatched scoring ability. Through five games, Hawkins has thrown for seven touchdowns against just one interception while crossing the plane himself for 11 more scores.

Arizona’s defense is getting too much credit for the team’s 4-1 start. Despite that hot start, the Wildcats have given up 52 points across two road games, with both opponents poking holes in their defense. Washington State threw for 241 yards in Week 4, whereas BYU ran for 148 in the second game of the season.

Hawkins will take what’s given to him, and Arizona doesn’t have the defensive capacity to limit him in all facets of the game. When the Wildcats load up the box, the Mountaineers’ pivot has the wherewithal to air it out. When they deploy nickel schemes, Hawkins will get out and run.

We’re expecting the same game script we’ve seen in recent weeks. Arizona will have no problem putting up points, and it will be up to Michael Hawkins to keep the Mountaineers moving. We think Hawkins is worth the hype in Week 6.

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LaNorris Sellers (South Carolina Gamecocks): $7,200 DraftKings

There are a handful of premier quarterbacks available in the $8,000 range on this week’s main slate. Shockingly, LaNorris Sellers is not one of them. The South Carolina Gamecocks’ quarterback is coming off his best fantasy performance of the season. We predict another monumental effort against the Florida Gators’ porous defense.

Sellers has been in the Heisman Trophy conversation in each of the past two seasons. After his breakout freshman campaign, in which he threw for over 2,500 yards and ran for 674, people have been expecting big things from the South Carolina native. While he has yet to climb college football’s most daunting hill, Sellers continues to deliver quality fantasy performances week after week.

Most recently, Sellers threw for 226 yards and two touchdowns while trampling the Kentucky Wildcats for 147 rushing yards on just 17 carries. That brings his season totals to 1,059 passing yards, 391 rushing yards, and nine scores. Surely, those numbers will soar after Sellers is done with Florida.

The Gators have one of the most toothless defensive units in the country. So far, they’re giving up 393.0 yards per game and have looked particularly ineffective against the pass. Opponents are averaging 255.4 passing yards per game against Florida, a figure that jumps to 296.3 against FBS foes.

LaNorris Sellers is primed for his best performance of the season. While he needs many more performances like that before he can be taken seriously as a Heisman Trophy contender, Week 6 could mark the start of his ascent.

CFB DFS Running Back Picks

Nate Sheppard (Duke Blue Devils) $9,700 DraftKings

Inarguably, Nate Sheppard is the most cost-prohibitive option on the main slate. Still, we’re making the argument for his inclusion on any roster. The Duke Blue Devils’ running back has tormented opponents every time he’s stepped on the field, and he will steamroll the Georgia Tech Yellow Jackets on Saturday.

Sheppard has asserted himself as the preeminent fantasy contributor this season. Through four games, the sophomore has totaled 644 rushing yards on just 91 touches, equaling 7.1 yards per carry and 161.0 rushing yards per game. Naturally, that workload is complemented by elite scoring potential. Sheppard has found paydirt in all four contests, including two multi-touchdown performances.

As evidenced by its spineless efforts to date, the Yellow Jackets’ defense will not be able to contain Sheppard. Georgia Tech ranks 123rd in the country, getting burned for 189.0 rushing yards per game. Sadly, that number should increase after Week 6.

In Week 2, Tennessee’s DeSean Bishop gouged Georgia Tech for 147 rushing yards and two touchdowns. That’s the baseline for what to expect from Nate Sheppard on Saturday. Sheppard already has a 227-yard effort under his belt, and we wouldn’t be surprised if this is his best fantasy performance to date.

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Caleb Hawkins (Oklahoma State Cowboys) $7,100 DraftKings

I don’t think anyone expected the Oklahoma State Cowboys to have this kind of renaissance. Not even the Cowboys themselves. Yet here they are, ranked and heading into a Week 6 matchup as chalky -10.5 favorites over the visiting UCF Knights. As implied by the spread, that means plenty of usage for Caleb Hawkins.

Hefty favorites commonly turn to their run game more frequently to maintain possession, control the clock, and protect their lead. That’s exactly what we’re anticipating from the Cowboys in this one. In its most recent 41-24 triumph over West Virginia, Oklahoma State ran the ball 38 times on 65 offensive snaps, accounting for 58.5% of its playcalling. Predictably, Hawkins was the primary rusher out of the backfield.

In Week 4, the Cowboys’ running back toted the ball 31 times for 180 yards and a score. That was the second time in his past three outings that Hawkins eclipsed the century mark, substantiating his increasing role on offense. We’ve also seen him involved in the passing attack, hauling in 11 receptions on 12 targets for a more modest 43 yards.

Oklahoma State is riding its leading rusher hard right now. Coming off a bye week, Hawkins is again expected to account for nearly 50.0% of the touches on offense. With that workload, he should have no problem reaching his fantasy ceiling and blowing past the production implied by his more modest salary.

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CFB DFS Wide Receiver Picks

Isaiah Mizell (Arizona Wildcats) $3,900

We’re offsetting some of the expensive fantasy options mentioned above with the premier value pick on the Week 6 main slate. Isaiah Mizell is one of four Arizona pass-catchers who play a primary role in its passing attack. Still, his recent performances make the case for a bigger role.

Through five weeks, Mizell ranks third on the team in receptions, yards, and targets, all of which have increased dramatically since the start of the season. In Week 1, the sophomore saw just two targets against FCS opponent Northern Arizona. In his most recent outing, Mizell was targeted seven times and set a career best with 67 receiving yards. Moreover, he’s totaled 137 receiving yards, two touchdowns, 11 receptions, and 17 targets over his last three outings, accounting for virtually all of his fantasy production.

Noah Fifita has some choices to make when airing out the football. Clearly, Isaiah Mizell is the apple of Fifita’s eye and is earning more involvement with his reliable performances. We’re anticipating more of the same on Saturday as the Wildcats expose West Virginia’s lackluster secondary at home.

There are pricier Arizona receivers on the board, but we predict Mizell will be the most productive fantasy-wise in Week 6.

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Cayden Lee (Missouri Tigers) $6,900

We are going back to the Missouri Tigers well in Week 6. Even with 110 yards on eight receptions, Cayden Lee fell short of his fantasy ceiling against the Gators last time out. We’re anticipating a more robust fantasy showing from Lee as his Tigers host the Texas A&M Aggies.

While he shares responsibilities with Donovan Olugbode, Lee remains the primary driving force behind Mizzou’s passing attack. Lee leads the team in receptions (35), yards (522), and targets (44), all of which are on the rise following his latest outings. Over the last two weeks, the senior has 266 yards and two scores on 19 receptions and 22 targets. That production includes a staggering 86.4% catch rate and 31.4% target share.

Texas A&M isn’t the same defensive presence it was last season. The Aggies have already been exposed by Kentucky and LSU, giving up over 900 yards of total offense in those contests. More concerningly, 564 of those yards came through the air, further supporting the case for a massive showing from the Tigers’ aerial assault.

Lee’s 110-yard effort last week will be dwarfed by his fantasy performance in Week 6. He should have no problem breaking through the Aggies’ permeable secondary and will again be the primary target for Austin Simmons. Undoubtedly, Cayden Lee is a must-roster on the main slate.

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Junior Sherrill (Vanderbilt Commodores) $5,700

Our discounted approach to wide receivers continues as we shine a light on Junior Sherrill. The senior has been an integral part of the Vanderbilt Commodores’ offense early in 2026 and will be asked to do more against the Ole Miss Rebels.

Vandy returns home after an unsuccessful two-game road interlude. The Commodores dropped both contests but covered the spread in each. Those ATS victories were partly thanks to Sherrill’s involvement in the passing game. The Tennessee native hauled in seven of 12 targets for 107 yards and a score against Georgia last time out. The week prior, he had six receptions for 95 yards on seven targets.

That has been Sherrill’s usual standard since the start of the season. He’s recorded fewer than 94 yards only once, back in Week 1, when the starters were taken out partway through the second half in a comfortable win over Austin Peay. Since then, Sherrill has led the Commodores in receptions, targets, and yards in every game.

This isn’t the same championship-caliber defense we’ve seen from Ole Miss in seasons past. The Rebels gave up 498 yards to Florida last time out. Likewise, LSU and Louisville looked more than capable in earlier contests.

With a raucous home crowd behind him, we expect Junior Sherrill to deliver another game-changing performance. Don’t overlook this primary wideout at a diminished salary.

Pictured: Michael Hawkins
Photo Credit: Imagn